Endocrine Abstracts

The exact mechanism of the development of T2DM is still unclear, however, it is known that important role is played by both environmental and genetic factors. In this study we focused on describing the interactions between environmental and genetic factors and answering the question whether physical activity can modify the impact of the genes on the incidence of T2DM. We recruited 921 subjects (median age: 38 years; 49.7% man; mean BMI: 28.1) from the cohort 1000 Polish Longit...

Aim: In Hashimoto thyroiditis (HT) thyroid cells show abnormalities in the intracellular iodine metabolism, associated with the changes in the expression of key proteins involved in the biosynthesis of: thyroid peroxidase (TPO), thyroglobulin (Tg), sodium iodide symporter (NIS) and pendrin. The aim of the present study was to compare the expression of thyroid-specific genes, such as NIS and Tg, as well as pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF&#9...

Macrosomia is associated with pregnancy complications and is suggested to predict child’s and mother’s health. High birth weight (>4,000 g) has been associated to the risk of several major chronic diseases in future life including diabetes, cardiovascular disease or cancer. Additionally delivery of a large baby carries a risk of perinatal complications. The aim of this study was to obtain serum fingerprints of healthy pregnant women to identify early biomarkers o...